tosensitizer Vehicles for Photodynamic Cancer Therapy

Downlo mentous M13 phage can be engineered to display cancer cell–targeting or tumor-homing peptides h phage display. It would be highly desirable if the tumor-targeting phage can also carry anticancer to deliver them to the cancer cells. We studied the evolution of structures of the complexes between c filamentous M13 phage and cationic serum-stable liposomes that encapsulate the monomeric phoitizer zinc naphthalocyanine. At specific phage-liposome ratios, multiple phage nanofibers and lipoare interwoven into a “nanoweb.” The chemical and biological properties of the phage-liposome eb were evaluated for possible application in drug delivery. This study highlights the ability of nanow phage-liposome nanowebs to serve as efficient carriers in the transport of photosensitizers to cancer cells. Mol Cancer Ther; 9(9); 2524–35. ©2010 AACR.